In any case, regardless of the still debated role of the NLRP3 inflammasome in DSS colitis, it has been shown that NLRP3, ASC, and caspase-1 deficient mice do not develop colitis without DSS treatment, implying that isolated inflammasome impairment does not result in spontaneous intestinal inflammation [61]. The gene discussed is CASP1; the disease is colitis.