We extend the findings of Von Scheele et al. [8] to show that soluble levels of TLR2 are further elevated in severe compared with moderate COPD and that, in participants with COPD, soluble TLR2 levels are closely associated with sputum levels of CXCL8, which is the key neutrophil chemoattractant. Here, TLR2 is linked to chronic obstructive pulmonary disease.