CD4 and infection: There is plenty of evidences that to spread the infection the DCs transfer virus to CD4+ T cells, which sustain actively viral replication, via both vesicular uptake (called trans infection) and de novo production (called cis infection) (Garcia et al, 2008; Geijtenbeek et al, 2000; Hladik et al, 2007; Hu et al, 2004; Pope et al, 1994; Turville et al, 2004).