Using a P < 5 × 10−5 as a threshold for genome-wide significance, previously identified asthma-associated loci, ORMDL3/GSDML and IL1RL1/IL18R1 were shown to be associated with asthma [Gudbjartsson et al., 2009; Moffatt et al., 2010]. The gene discussed is IL1RL1; the disease is asthma.