Moreover, in sharp contrast to the much cheaper and more widely tested generic lipid- and blood pressure–lowering agents (e.g., in Europe, simvastatin costs at little as €5 per year, compared to more than €10,000 per year for TNFα-blocking agents), these new agents are very expensive and are not effective in ∼30% of RA patients (27). The gene discussed is TNF; the disease is rheumatoid arthritis.