In fact, patients with luminal A [steroid hormone receptors positive, HER2 negative, low proliferative activity] breast cancer usually show a very low rate of pCR, but their prognosis remains good even when no pCR is achieved (Angelucci et al. 2012; Colleoni et al. 2009; Huober et al. 2010; Precht et al. 2010; Straver et al. 2010; Kim et al. 2010; von Minckwitz et al. 2012). The gene discussed is ERBB2; the disease is breast cancer.