To be clear, the shared epitopes themselves consist of two sub-classes of epitopes—the differentiation antigens (such as tyrosinase), which are shared between normal tissues and tumors, and the “cancer testes” or CT antigens (such as MAGE and NY-ESO1), which although un-mutated are expressed on germinal tissues and cancers, but not on normal adult tissues. The gene discussed is TYR; the disease is cancer.