Hence, RNA interference mediated knock-down of V600EBRAF leads to senescence or apoptosis [15-17], and more recently, the BRAF inhibitors PLX4720 and its analog for clinical use vemurafenib (also known as PLX4032 or RG7204) were shown to inhibit V600EBRAF with high affinity, causing cell death to melanoma cell lines in vitro[18,19], regression of metastatic melanoma in preclinical models [20] and prolonged survival of melanoma patients [21]. This evidence concerns the gene BRAF and melanoma.