To determine whether loss of E-cadherin expression in human breast cancer cell lines is associated with differential expression of miRNAs, we compared 10 E-cadherin mutant cell lines with 17 wild-type cell lines within the luminal-group of cell lines (Figure 4A) and compared nine E-cadherin promoter hypermethylated cell lines with eight nonmethylated cell lines within the ER-negative/basal-group (Figure 4B). The gene discussed is CDH1; the disease is breast cancer.