To do so usually requires the administration of FVIII 10–15 U/kg/daily or 20–40 IU/kg every second day or at least three times weekly for patients with haemophilia A and every third day or twice weekly for patients with haemophilia B. “Inter-mediate-dose protocols” are exemplified by protocols developed in The Netherlands, use lower doses administered slightly less frequently (e.g., 15–25 IU/kg, 2–3 times/week). Here, F8 is linked to hemophilia A.