Immunofluorescence method was employed to detect OCT4 expression in lung adenocarcinoma tissues.The relationship between OCT4 expression and clinical pathological indicators is examined through chi-square test.Moreover, the survival rate is calculated through the Kaplan-Meier survivorship curve.Finally, the relevance between the indicators and patient survival is estimated using Cox analysis. This evidence concerns the gene POU5F1 and lung adenocarcinoma.