DES and hepatocellular carcinoma: In this present study, our immunohistochemical analysis displayed various distribution and expression intensity of four most prominent HSCs phenotype/gene markers including α-SMA, desmin, GFAP and vimentin [14] as well as a recently reported marker vinculin [26], which probably exhibited their different in vivo biological behaviors and cellular response to injurious stimuli in the progress of HCC.