Comparing the contexts of the mutations obtained with the individual deaminases in yeast to those of the kataegic mutations in the cancers reveals that APOBEC3B has a signature that fits extremely well with the kataegis in PD4107a and PD4103a whereas APOBEC3A fits better with PD4199a (p values in all three cases <0.005) (Figure 3D). Here, APOBEC3B is linked to cancer.