In these adult women with PCOS, the blockade of androgen action by flutamide administration restored the sensitivity of GnRH to estradiol and progesterone, thus supporting the role of an increased androgenic activity mediated by the androgen receptor (AR) to reduce the progesterone negative feedback at the level of the GnRH pulse generator [18,21]. The gene discussed is AR; the disease is polycystic ovary syndrome.