As we have demonstrated in ACC-M cells, the synthesis and translocation of the NF-κB protein were highly specifically suppressed by transfecting the cells with the use of a pBαbe-SR-IκBα plasmid, and this blocking effect persisted following irradiation and hence when the NF-κB pathway was activated. The gene discussed is NFKBIA; the disease is adrenal cortex carcinoma.