Hop (Hsp70/Hsp90 organising protein), also called stress-inducible protein 1, which interacts with HSP70 and HSP90 was overexpressed in human colonic carcinoma (22), invasive pancreatic cancer cell lines and malignant tissues of pancreatic cancer patients, and knockdown of Hop gene may decrease the invasiveness of pancreatic cancer cells, possibly by means of modulation of HSP90 activity (23). This evidence concerns the gene HSP90AB1 and familial pancreatic carcinoma.