The AUC of the ROC curves for the other 6 genes (SIX6, SOX1, RARB, BCL2, PHOX2A and FOLX2) ranged from 0.573 to 0.667; the sensitivity of each gene ranged from 29.70 to 51.49% and the specificity ranged from 73.33 to 93.33%, if they were used separately to diagnose stage I NSCLC. This evidence concerns the gene SIX6 and non-small cell lung carcinoma.