To explore the possible pathway through which gene methylation promotes the carcinogenesis and progression of NSCLC, we investigated the expression of 8 classical components (VEGF, HER-2, P53, P21, EGFR, CHGA, SYN and EMA) of common oncogenic pathways in 92 cases of stage I NSCLC using immuno histochemistry. This evidence concerns the gene TP53 and non-small cell lung carcinoma.