This study showed that 7 genes (MYF6, SIX6, SOX1, RARB, BCL2, PHOX2A and FOLX2) were frequently methylated in 101 cases of patients with stage I NSCLC, while rarely methylated in 30 patients with non-cancerous lung diseases. The gene discussed is MYF6; the disease is non-small cell lung carcinoma.