In a similar study performed in china in 2001, IGF-1 level was evaluated in patients with chronic liver disease and cirrhosis; lowest IGF-1 level was observed in patients with cirrhosis and also showed a relation with serum albumin level, to the extent that a severe decrease in IGF-1 level was seen at albumin level of < 3g/dL (26). The gene discussed is ALB; the disease is Cirrhosis.