A more direct indication for the asymmetric expression of CK2 subunits comes from the studies of Deshiere et al. (2012) who noted that the CK2α′:CK2α:CK2β ratio varies across breast cancer samples, and that a higher CK2α:CK2β ratio correlates with the expression of epithelial-to-mesenchymal transition markers [10]. The gene discussed is CSNK2B; the disease is breast cancer.