GHRL and chronic obstructive pulmonary disease: In a multicenter, randomized controlled trial (RCT) study carried out in lean COPD patients (n = 33), intravenous injections of ghrelin (2 μg/kg, twice a day) for three weeks resulted in an increase in the food intake, with consequent recovery of the body weight and FFM, along with strengthening of the respiratory muscles [43].