Analysis of patients with HF-reduced EF (<40%) in the GWTG-HF program reported an impressive rate of 65.3% ACE-inhibitor or ARB use at admission and 92.9% at discharge and a rate of 72.6% beta-blocker use at admission and 94.6% at discharge in patients eligible for medical therapy without contraindication [128]. The gene discussed is ACE; the disease is hydrops fetalis.