In contrast to primary tumors there was a trend of higher p110α levels in non-amplified neuroblastoma cell lines (SK-N-AS and SK-N-F1) compared to cell lines with 2p-gain (SH-SY-5Y and NB69) or MYCN amplification (SK-N-DZ and SK-N-BE) (Figure 1C). The gene discussed is MYCN; the disease is neuroblastoma.