Studies of human cancer cell lines have now confirmed that LGR5 promotes the growth and/or survival of colorectal and basal cell carcinoma (McClanahan et al., 2006; Tanese et al., 2008), glioblastoma (Nakata et al., 2013), and neuroblastoma (Balamuth et al., 2010). The gene discussed is LGR5; the disease is neuroblastoma.