To determine if high levels of LGR5 are associated with a more aggressive clinical course, retrospective studies of archived tumors were undertaken and showed diminished survival in gastrointestinal carcinoma and glioblastoma patients whose tumors expressed high levels of LGR5 (Becker et al., 2010; Wu et al., 2012; Nakata et al., 2013). Here, LGR5 is linked to digestive system carcinoma.