In addition, promoter hypermethylation and loss of function mutations in LGR5 and LGR6 have been discovered in some colorectal tumor samples, again suggesting that these genes could act as tumor suppressors in some contexts (Sjoblom et al., 2006; Chan et al., 2008; de Sousa et al., 2011). The gene discussed is LGR5; the disease is colorectal neoplasm.