KITLG and infection: Members of the SCF-E3 ubiquitin ligase complex, in particular SKPA, CULLIN-1 and SLIMB, have been previously reported to function as repressors of AMP production in uninfected flies [26] and proposed to repress the Imd pathway by promoting the ubiquitylation and subsequent degradation of a constitutively active Relish protein, as well as down-regulating AMP production after infection in vivo [26].