While hepatic fibrosis is impaired in S. mansoni-infected mice unable to signal through IL-4Rα (Il-4rα−/−), it is ablated in mice treated with soluble IL-13Rα2-Fc and also fails to develop in mice deficient in IL-13 (Il-13−/−) (Chiaramonte et al., 1999; Jankovic et al., 1999; Fallon et al., 2000). Here, IL13 is linked to Hepatic fibrosis.