SOD1 and amyotrophic lateral sclerosis: Impaired microglial function is also reported in amyotrophic lateral sclerosis (ALS), where microglia derived from mutant superoxide dismutase 1 (SOD1) mouse, an established disease model of ALS, induce more oxidative stress and cause higher neuronal loss compared with wt microglia (Beers et al., 2006).