Again, we found that the expression of the early adipogenic genes C/EBPβ and C/EBPδ was up-regulated in HGPS samples at the levels comparable to the controls, and the transcription activation of C/EBPα and PPARγ2 was suppressed in HGPS (Figure 5C). The gene discussed is PPARG; the disease is Hutchinson-Gilford progeria syndrome.