We have previously shown that in adulthood, Sema3A and 3F mRNA expression is absent in white matter, but re-expressed in MS lesions in a differential way in different lesions, with active lesions (more inflammatory and more likely to remyelinate) containing higher mRNA expression of the chemoattractant Sema3F than Sema3A, and chronic active lesions (less inflammatory and less likely to remyelinate) with higher mRNA expression of the chemorepellent Sema3A than Sema3F [54]. Here, SEMA3A is linked to myeloid sarcoma.