GATA3 downregulation was associated with decreased expression of other transcription factors, like the psoriasis susceptibility gene TNFAIP3 and the Notch ligand jagged 2 (both acting as negative regulators of inflammation), and genes regulating epidermal differentiation, such as the transcription factor AP2-α (TFAP2A) and apoptosis-inducing FAS ligand. This evidence concerns the gene GATA3 and psoriasis.