In fact, in hepato-cellular carcinoma (HCC), ANX2 has been proposed as a differential diagnostic marker, in combination with glypican-3 (GPC3), glutamine synthetase (GS) and heat shock protein 70 (HSP70) [65,85,86,90,93,98,100-104]. The gene discussed is ANXA2; the disease is hepatocellular carcinoma.