However, the MITF isoform ENST00000352241 was found to be significantly overexpressed in melanoma compared with melanocytes (FC = 3.4), whereas the transcript variants ENST00000433517 (FC = -5.6) and ENST00000472437 (FC = -3.4) were underexpressed in melanoma (Figure 4A). The gene discussed is MITF; the disease is melanoma.