Taking tumor size, tumor stage, histologic grade, Milan criteria, pre-LT serum AFP level, micro-vascular invasion and miR-20a as covariates, that were found to be significant in univariate analysis, we found that decrease miR-20a expression (HR = 4.937, P = 0.022; Table 2), tumor size (HR = 1.175, P = 0.035; Table 2), pre-LT serum AFP level (HR = 1.569, P = 0.031; Table 2) and micro-vascular invasion (HR = 2.671, P = 0.009; Table 2) were significantly associated with OS and that the prognostic value of miR-20a was independent the microvasculuar invasion. Here, AFP is linked to neoplasm.