CLEC1B and cancer: The available studies suggest that ligation of the CLEC-2 receptor contributes to all these effects; (i) CLEC-2 ligation seems to affect endothelial cells and vessel formation during embryogenesis, as well as during cancer metastasation [26,27,28,31,32], and direct or indirect effects on the endothelium may contribute to local swelling and extravasation; (ii) activation of immunocompetent cells may be an important local proinflammatory effect; and (iii) platelet activation may cause microthrombi, ischemia and necrosis.