There are also reports that 5 mg/kg/d of PD123319 decreased atherosclerosis in diabetic apoE −/− mice [15], while 30 mg/kg/d of PD123319 did not affect systolic blood pressure in C57BL/6 mice infused with AngII 500 ng/kg/min [37]. The gene discussed is APOE; the disease is atherosclerosis.