To increase our knowledge on the role of CRH in ADNFLE, we performed a mutation screening of the CRH gene in an Italian family showing a typical form of ADNFLE without psychiatric comorbidities (thus excluding an involvement of the KCNT1 gene) and where mutations in the nAChR genes were excluded. This evidence concerns the gene CHRNA4 and autosomal dominant nocturnal frontal lobe epilepsy.