TNF and neoplasm: At day 8 after cell inoculation, tumor volume was similar in Hep-2/TIC group, Hep-2/CD group, Hep-2/TNF-α group and Hep-2/0 group (64.47±4.01 mm3, 65.37±2.66 mm3, 64.84±5.41 mm3 and 64.02±4.78 mm3, respectively); no significant difference was seen between each two of them (P>0.05).