Mutations in SLC12A6, the gene which encodes for the K–Cl cotransporter-3 (KCC3), results in a rare autosomal recessive neurological disorder known as Hereditary Motor and Sensory Neuropathy/Agenesis of the Corpus Callosum (HSMN/ACC) (OMIM 218000; [16], [17]). This evidence concerns the gene SLC12A6 and motor peripheral neuropathy.