RYR1 and neoplasm: As shown in Figure 4, we found that high tumor CcO activity was not associated with age (hazard ratio, 0.24; P = 0.14), gender (hazard ratio, 0.58; P = 0.42), the treatment administered (hazard ratio, 0.39; P = 0.05), or MGMT promoter methylation status (hazard ratio, 1.28; P = 0.74).