RYR1 and neoplasm: The median overall survival among patients with low tumor CcO activity was 17.15 months (95% CI, 13.16 to 17.61), as compared with 6.3 months (95% CI, 4.77 to 6.69) among patients with high tumor CcO activity (P<0.0001 by the log-rank test) (Figure 4A).