Indeed, 3-hydroxy-3-methylglutaryl-CoA reductase is under the transcriptional control of the sterol regulated element binding protein-2, which is regulated by intracellular sterol levels, and by transcription factors such as HIF-1α [33], which can be constitutively activated in MDR+ tumor cells [34] (see also below). This evidence concerns the gene HMGCR and neoplasm.