In many of these, a comparison of a wild type (usually PAO1) and a variety of QS-deficient strains suggest that QS-controlled virulence factors are important in the pathogenesis of infection, and that most QS mutants are less virulent than wild type P. aeruginosa. It is unquestionable that QS controlled biofilm formation and virulence factor production plays an important role in bacterial virulence, particularly in clinical settings such as cystic fibrosis (CF) (e.g. [7]). The gene discussed is SMOX; the disease is infection.