CXCL12 and neoplasm: Remarkably, BALB/c mice and BALB/c×AKR mice showed wound-promoted tumor growth, and levels of SDF-1α increased 2-fold or more between day 2 and 9 after wounding, while strains that did not show wound-promoted tumor growth (BALB/c×C57Bl/6, BALB/c×DBA, and BALB/c nu/nu) only had a 1.1- to 1.3-fold increase in SDF-1α levels (Fig. 4D).