Taken together, our data suggest that increased SDF-1α/CXCR4 signaling is an important contributor to wound-promoted tumor growth of 4T1-derived mammary tumors in mice, and that an increase of SDF-1α level in response to wounding may represent a predictive marker of post-surgical growth of residual tumor tissue in the proximity of the wound. This evidence concerns the gene CXCR4 and neoplasm.