CXCL12 and neoplasm: We observed a multifaceted effect of SDF-1α and AMD3100 on tumor growth: tumor cell proliferation, collagen deposition, and neoangiogenesis were increased by SDF-1α and decreased by AMD3100 regardless whether cells were treated with SDF-1α or AMD3100 in vitro or exposed to wound-derived SDF-1α or AMD3100 in vivo.