To explore the involvement of IL-6 in gastric carcinogenesis, we performed an immunohistochemical analysis of IL-6 in 5 cases of Helicobacter pylori–negative healthy control, 5 cases of Helicobacter pylori–positive gastritis, 5 cases of gastric adenoma, and 31 cases of gastric cancer. Here, IL6 is linked to gastric adenoma.