However, numerous other factors may also have caused the observed heterogeneity, such as differences in genotype methods, source of controls, ethnicity, etc. In view of the conflicting results from previous studies and the insufficient statistical power of the previous meta-analysis, we performed this updates meta-analysis to provide a more comprehensive and reliable conclusion by reevaluating the association between ESR1 gene polymorphisms and susceptibility to endometrial cancer. Here, ESR1 is linked to endometrial cancer.