Afterwards, we examined the effects of artemether combining with shRNA interference of VCAM-1 (shRNA-VCAM-1) on the cell migration, invasion, the expressions of MMP-2/9, phosphorylated Akt (p-Akt) and cell apoptosis, aiming at providing novel experimental evidence for the treatment of human brain glioma. Here, VCAM1 is linked to brain glioma.