The interaction of INI1 with the PIC is probably an early event since it was shown that INI1 is incorporated in mature virions [39], that HIV-1 infection triggers the nuclear export of INI1 which associates with the incoming HIV-1 PICs [56] and that INI1 is present in the reverse transcription complex [57]. The gene discussed is SMARCB1; the disease is HIV-1 infection.