APOE and cardiovascular disorder: In addition, other genes associated with lipid control and regulatory regions such as Upstream Transcription Factor 1 gene (USF1), Apolipoprotein E gene (APOE), Lipoprotein Lipase gene (LPL), Fibrinogen Beta Chain gene (FGB), and Hepatic Lipase gene (LIPC) can manifest as hypercholesterolemia and have been shown to predispose to premature cardiovascular diseases [10], [11], [12], [13], [14].