Recent studies utilizing human samples and cellular and animal models of NPC revealed interesting parallels between AD and NPC neuropathogenesis, which include endosomal/lysosomal dysfunction, glial-mediated inflammation, NFTs and Aß accumulation especially in ApoE ε4 carriers, cholesterol dyshomeostasis, and cell cycle reactivation [27], [28], [39], [43]. The gene discussed is APOE; the disease is Alzheimer disease.