Atherosclerosis is characterized by localized accumulations of lipids, inflammatory cells, smooth muscle cells and calcified cell debris [3], while Alzheimer’s disease (AD) is characterized by aberrant oligomerization/polymerization of two misfolded proteins–extracellular amyloid-beta (Aß) assembled into amyloid deposits, and intracellular hyperphosphorylated tau assembled into neurofibrillary tangles [4]–[6]. Here, MAPT is linked to Alzheimer disease.