AKT1 and neoplasm: In cancer, miRNAs can act as either an oncogene or a tumor suppressor, as evidenced by miR-130b promoting liver cancer stem cells (CSCs) growth and self-renewal via targeting TP53INP1 [10], miR-34a inhibiting prostate cancer metastasis by directly repressing CD44 [11], and miR-7 inhibiting tumor growth and metastasis by affecting the the phosphoinositoide-3 kinase (PI3K)/AKT pathway in hepatocellular carcinoma [12].