NR1H4 and primary biliary cholangitis: As an FXR agonist and an analogue of a primary human bile acid (chenodeoxycholic acid) and other cholic acid derivatives which are involved in modulating lipid, glucose and bile acid homeostasis, INT-747 has been clinically shown to improve liver function in patients with primary biliary cirrhosis (http://www.interceptpharma.com/) and is being evaluated for the treatment of nonalcoholic steatohepatitis (NASH) (http://www.interceptpharma.com/); a disease often associated with IR [54].