NR4A3 and Hand-foot syndrome: From the genes significantly altered in HFS group vs 6-OHDA (Table S3), 5 displayed a more than 2-fold increase: Ttr (transthyretin), Sostdc1 (sclerostin domain containing 1), Aqp1 (aquaporin 1), Nr4a3 and Igf2 (insulin growth factor 2); Ttr and Sostdc1 showing the highest fold change: 279 and 26, respectively.